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We additionally summarize the evidence by domain and certainty level in a structured Supplementary Table 6, explicitly separating relatively robust short-term metabolic evidence from more exploratory reproductive and periconception safety findings

It also supports basal stem cells in the skin

The glutathione (GSH) antioxidant system plays an important role in mitigating ROS

So, unlike topical self-tanners that tint the outer layer of your skin and dont have any internal, systemic effects, melanotan is acting within the cells of the body just like UV radiation